Comparison of Metronidazole and Furazolidone Against Giardia lamblia in Children

Giardia lamblia infections in children in Ghana

INTRODUCTION Though giardiasis is an important public health problem in Ghana, several aspects of its epidemiology, particularly the molecular epidemiology has not been investigated adequately. This could be a major hindrance to effective surveillance and control of giardiasis in the country. The study was carried out to determine the prevalence, risk factors and genotypes of Giardia lamblia in...

A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia.

Giardiasis is one of the most common causes of diarrheal disease worldwide. Treatment is primarily with 5-nitro antimicrobials, particularly metronidazole. Resistance to metronidazole has been described, and treatment failures can occur in up to 20% of cases, making development of alternative antigiardials an important goal. To this end, we have screened a chemical library of 746 approved human...

ZINC DEFICIENCY IN CHILDREN INFECTED WITH GIARDIA LAMBLIA

Giardia, a protozoan parasite, resides in the small intestine in man. This parasite damages the mucosal intestinal surface and in severe cases produces malabsorption and it may also affect mineral absorption, especially zinc. In this study a total of 118 infested and 43 non-infested persons as a control group were selected. From each patient a 5 ml blood sample was obtained. The serum was ...

Giardia Lamblia.

Isolation, excystation and axenization of Giardia lamblia isolates: in vitro susceptibility to metronidazole and albendazole.

From 53 samples of human faeces containing Giardia lamblia cysts, 18 isolates were successfully excysted in vitro, and cultivated axenically in TYI-S-33 modified medium. The in vitro effects of metronidazole and albendazole on these isolates were evaluated by the trophozoite adherence inhibition method. The IC50 was between 2.4 and 11.5 micro M for metronidazole and 0.027 and 0.192 micro M for ...